Xenical Information For Slimming
The following Xenical frequently
asked question section is for informational purposes only. The
information has been compiled from a variety of resources in order
to give the reader an overview of the use and various effects
of Xenical to help individuals lose weight fast.
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Why is is Xenical prescribed?
Xenical (orlistat) is a weight control medication that has been
approve by the United States Federal Drug Administration, as well
as, been extensively tested throughout Europe. Distinct from other
medicines that stimulate the brain to suppress appetite, Xenical
uses a fat blocking mode of action that works non-systematically
in the gastrointestinal tract. The end result is approximately
30 percent of dietary fat passes through the body undigested.
Therefore, Xenical blocks some 30% of the calories from fat from
being absorbed allowing individuals to lose weight fast.
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Why is Xenical sometimes referred to as orlistat?
Orlistat is the generic name for Xenical. The generic name represents
the medications nonproprietary or chemical name, whereas, the
brand name is the name a pharmaceutical give to a medication for
marketing purposes. back to the top of the page
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How does Xenical work?
Distinct from other medications that effect neurotransmitters
to stimulate the brain to suppress appetite. Xenical uses a fat
blocking mode of action that works non-systemically in the gastrointestinal
tract. Dietary fats are large molecules that must be broken down
by enzymes, called lipases, before they can be absorbed into the
bloodstream. Xenical interferes with these lipases by forming
covalent bonds with the them in the stomach and small intestine,
this essentially inactivates the enzymes so they are no longer
available to hydrolyze dietary fat into an absorbable state. Thus,
allowing for some 30 percent of dietary fats to pass through the
gastrointestinal tract unchanged. *Xenical works here, covalently
bonding to the pancreatic lipasesback to the top of the page.
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What clinical studies have been completed?
Xenical was evaluated in a placebo-controlled, double blind study
to examine the effectiveness of a medication for weight loss and
the prevention of weight regain over a two-year period.
During the first year, participants who met the definition of
obese were placed on a low calorie diet while randomly given a
placebo or orlistat. Research following the first year indicated
those individuals treated with orlistat (120 mg per dose) lost
approximately two-thirds more weight than the control (placebo)
group.
In the second year, participants were placed on a weight maintenance
diet and the orlistat group was randomized to receive either a
placebo or different doses of orlistat. Results following the
second year indicated the individuals on orlistat, 120 mg per
dose, three times per day were two times as likely to keep the
weight off as those individuals in the control (placebo) group.
"This study demonstrates that partial inhibition of fat absorption
in obese subjects can produce sustained weight loss," the
authors conclude. "Subjects treated with orlistat plus a
mildly controlled-energy diet lost significantly more weight than
those treated with placebo plus diet even though all subjects
received a high standard of care and similar dietary counseling…These
observations collectively suggest that orlistat may be a useful
adjunct to dietary intervention in producing and maintaining weight
loss over two years."
Journal of the American Medical Association (JAMA. 1999;281:235-242)
Recent study in Switzerland revealed the following:
- Basel, Switzerland -- The weight loss
medication Xenical helps patients achieve rapid and sustained
weight loss according to the results of a new study designed
to reflect real world usage of Xenical in clinical practice.(1)
- The 12 month study of 430 overweight
men and women (BMI of 30-43 kg/m2), was designed to assess the
effectiveness of Xenical in patients who are responsive to treatment.
Patients who achieved 5 per cent (approximately 5kg) weight
loss after 3 months and maintained this after a further 3 months
of Xenical treatment, were followed for one year. During this
time weight loss and other health improvements, such as reductions
in blood pressure, were assessed. The results suggest that the
efficacy of Xenical in a real-life clinical practice setting
is even greater than that demonstrated previously in clinical
trials:
- The greatest weight loss was seen
in the first four weeks of treatment, with an average weight
loss of 4.1 kg
- Three out of four people achieved
5 per cent weight loss by month three, losing an average of
8kg
- By month 6, 92 per cent of these people
had maintained at least 5 percent weight loss, with an average
weight loss of 10.9kg
The average weight loss after one year
was 11.6 kg. One in two patients in the study lost more than 10
per cent of their initial weight, and over 8 in ten people lost
more than 5 per cent -- an amount of weight loss shown to clinically
improve the health and well-being of overweight people.
Commenting on the results, lead study investigator
Professor Hermann Toplak from the Karl-Franzens-Universitat, Graz,
Austria said, "These results demonstrate the significant
benefits of rapid and continuous weight loss with Xenical in a
clinical practice setting. Patients who respond rapidly to treatment
continue with treatment and achieve long-term success."
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Are there any other benefits to taking Xenical other than
weight reduction?
Yes, studies have shown that even a modest weight loss as a result
of Xenical and diet can significantly reduce the following life-risk
factors:Reduction of blood glucose levels (decreasing the risk
of diabetes)
Lowering of diastolic and systolic blood pressure (decreasing
the risk of heart disease and strokes)
Reduction in blood cholesterol levels (decreasing the risk of
heart disease and strokes)
Reduction of blood levels of uric acid (decreasing the risk of
gout)
Reduction in the cases of sleep apnea (irregular breathing during
sleep)
Weight reduction is also likely to improve appearance, which has
a positive affect on self-esteem and motivation.
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Which individuals benefit from Xenical?
Xenical is appropriate for those individuals who are considerably
overweight, 30 percent above their ideal weight or a body mass
index of 30 or greater. Xenical may also be appropriate for those
individuals who are overweight, 20 percent above their ideal weight
or a body mass index of 27 or greater, and also have significant
risk factors such as high blood pressure, high cholesterol or
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How does one determine their body mass index (BMI)?
BMI is calculated by dividing an individual's weight in kilograms
by their height in meters squared. The following chart can assist
individuals in calculating their BMI: Locate the appropriate height
in the left-hand column of the chart. Proceed across the top row
of the chart to the appropriate weight. The number where these
variables meet is the BMI. For example, an individual who weighs
190 lbs. and is 5'6" would have a BMI of 31.
Body Mass Index Chart
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What is the appropriate dose of Xenical?
The recommended dose of Xenical is one 120-mg capsule taken with
each meal that contains fat. Individuals may take Xenical in combination
with a moderately reduced calorie diet up to three times per day.
In the event, a meal is without fat content or a meal is periodically
missed an individual may omit that dose. Doses in excess of 120
mg three times per day have not proven to advantageous to weight
reduction. For the best results, individuals should practice eating
a well-balanced, moderately reduced calorie diet that contains
no more than 30 percent of the calories from fat.
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How long should an individual take Xenical?
Xenical has been proposed as a long-term treatment option for
individuals who suffer from obesity. Orlistat, the active ingredient
in Xenical is believed to be safe because systemic exposure is
minimal. In fact, approximately 97% of the administrative dose
of orlistat was found excreted in the feces, 83% of that was found
to be chemically unchanged orlistat. However, the use of Xenical
for more than two years has not been studied so extended use of
the medicine, in excess of two years, is not recommended at this
time.
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What about missed doses?
If an individual forgets to take their medication, he or she should
take it immediately when they remember, provided no longer than
an hour has passed since the last meal. Do not double the dose
or change the prescribed dose without the recommendation of a
physician.
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What about an Overdose?
Single does of 800mg of Xenical and multiple doses up to 400mg
three times a day for over two weeks have been studied in normal
weight and obese patients without significant adverse findings.
Should a significant overdose of Xenical occur, individuals should
seek immediate medical attention.
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Does Xenical interact with other medications?
Xenical does not affect most commonly prescribed medications.
However, it is important for individuals to communicate with their
physicians concerning medications they are taking. This is relevant
since taking more than one medication at any given time can result
in drug interactions; medicines when combined can potentate or
lessen the effect of other medications. For example, Xenical potentates
the lipid lowering the affect of Pravastatin while it decreases
the absorption of the fat-soluble vitamins A, D, E, K and beta
carotene.back to the top of the page
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Should I supplement a multi vitamin with Xenical?
Yes, Xenical interferes with the absorption of some fat-soluble
vitamins. Therefore, it is recommended that individuals supplement
their diet with a daily multi-vitamin that contains vitamins A,
D, E, K plus beta-carotene. Multi vitamins should be taken once
per day approximately two hours before or after taking Xenical.
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When is it inappropriate to take Xenical?
Xenical is contradicted in the following circumstances: Individuals
who have been diagnosed with a decreased ability to absorb the
essential nutrients e.g. chronic malabsorption syndrome, tropical
sprue, idiopathic steatorrhea, etc.
Individuals with inflammatory bowel disease e.g. Crohn's disease
and ulcerative colitis.
Individuals with complications of the bilary tract including the
gallbladder.
Individuals with organic causes of obesity, such as hypothyroidism.
Women who are pregnant or breastfeeding.
Individuals who have eating disorders e.g. anorexia, bulimia,
etc.
Individuals who have had allergic reactions to orlistat or any
of the active ingredients in the medication.
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Should Xenical be taken during pregnancy or while breastfeeding?
The safety of Xenical has not been established in pregnant women,
therefore Xenical should not be used in women who are trying to
get pregnant or in women who are pregnant. Women should not take
Xenical while breastfeeding their infant because it is not known
whether Xenical is excreted in the breast milk.
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Does Xenical interact with the use of birth control pills?
No, there has not been any clinical data to suggest that Xenical
would decrease the effectiveness of birth control pills. Is Xenical
appropriate for pediatric or geriatric populations? The safety
and efficiency of Xenical in the pediatric population have not
been established. In addition, clinical studies concerning Xenical
did not include a sufficient number of elderly individuals age
65 years and older to determine whether they respond differently
from younger individuals. So at this time pediatric and geriatric
populations should refrain from using Xenical until more studies
are completed.
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How is Xenical supplied?
Each capsule contains 120 mg of the active ingredient orlistat.
The capsule also contains the inactive ingredients microcrystalline
cellulose, sodium starch glycolate, sodium lauryl sulfate, povidone
and talc. The capsule shell consists of gelatin, titanium dioxide
and FD2C Blue No.1.
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Can I get Xenical over the counter?
No, Xenical is a prescription medication and should only be taken
when prescribed by a licensed physician. Regulations do not permit
Xenical to be taken without a prescription. Secondary to the advent
of the internet individuals can now order lifestyle medication,
such as, Xenical online. Individuals are ask to complete a medical
questionnaire which is subsequently reviewed by a physician, once
approved your Xenical order will be shipped discreetly to your
home or office in 1-2 business days. (order Xenical online now)
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How should Xenical be stored?
Xenical should be stored at 25*C (77*F); excursions permitted
to 15* to 30*C (59* to 89* F). The bottle should be kept tightly
closed and the medication should not be used after the given expiration
date. Xenical, like all medications, should be kept out of the
reach of children. back to the top of the page
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What is Olestra?
Olestra is often confused with orlistat. Secondary to the similarity
of the names. Olestra is not a diet medication; the substance
is a non-absorbable fat substitute used in snack foods.
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