Cialis Information For Impotence Treatment
The following Cialis frequently asked question
section is for informational purposes only. The information has
been compiled from a variety of resources in order to give the
reader an overview of the use and various effects of Cialis for
the treatment of male impotence.
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What is Cialis?
Cialis represents a new class of medications
known as PDE-5 inhibitors. These medications are used to treat
erectile dysfunction (impotence). Cialis has been approved by
the European Commission and the Federal Drug Administration for the treatment of
male impotence. Superior to Viagra Cialis works up to 36
hours. Called the "weekender impotence pill" men can now just take
Cialis for up to 36 hours of impotence treatment.
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Why is Cialis sometimes referred to as tadalafil?
Tadalafil is the generic name for Cialis. The
generic name represents the medications nonproprietary or chemical
name, whereas, the brand name is the name a pharmaceutical give
to a medication for marketing purposes.
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What is the appropriate dose of Cialis?
During clinical testing Cialis was administered
in 10mg or 20mg doses.
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What are the results of the clinical
trials concerning the percentage of men who had improved erections
while taking Cialis?
The Phase III study examined the safety and
efficacy of "on-demand" Cialis treatment in 196 men
suffering from mild-to-severe ED(1). Men in the study were randomized
to receive up to 20 mg of Cialis or placebo over a 12-week period.
Men were free to take their study medication without restrictions
on food or alcohol consumption and to have sex with their partners
at the time of their choosing after each dose.
Results showed that 85 percent of men taking
Cialis 20 mg reported significantly improved erections compared
with baseline. In addition, 78 percent of intercourse attempts
recorded by all men on Cialis 20 mg were successful. Importantly,
63 percent of men with ED treated with Cialis 20 mg achieved an
erectile function score experts consider "normal" for
healthy men as measured by the International Index of Erectile
Function (IIEF).
In this study, side effects were mild to moderate,
and their incidence diminished with continued treatment. The most
commonly reported side effects were backache, muscle ache and
upset stomach. There were no clinically significant changes in
blood pressure, heart rate, electrocardiograms or laboratory tests
attributable to treatment with Cialis.
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How long does it take to notice the effects of Cialis
once I take the medication?
During clinical studies most men were able
to achieve an erection within thirty minutes of taking Cialis.
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How long does the effects of Cialis last?
In a Phase III clinical study designed to evaluate
the efficacy of Cialis at specific time points after dosing, 348
men with mild-to-severe ED were randomly assigned to receive Cialis
20 mg (n=175) or placebo (n=173) over approximately an eight-week
period. Patients were instructed to attempt intercourse with their
partners on four specific occasions: on two occasions at 24 hours
after dosing and on two occasions at 36 hours after dosing. The
primary endpoint was the percentage of successful sexual intercourse
attempts.
"Cialis was statistically superior to placebo
in enabling men with ED to have successful intercourse at 24 or
36 hours after taking the drug and showed a consistent effect
at both time points," said Raymond Rosen, Ph.D., study author
and director of the Program in Human Sexuality at the University
of Medicine and Dentistry of New Jersey and professor of psychiatry,
Robert Wood Johnson Medical School, Piscataway, New Jersey. "Also,
in this study, the duration of effectiveness did not appear to
influence the incidence or severity of side effects."
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How long does the effects of Cialis last?
Clinical studies have shown the effects of
Cialis can last from 24 to 36 hours. This enables men to put the
spontaneity back in thier love life.
Please note: following climax the erection will
return to the normal flacid state. Cialis, following the recovery
phase, can enable men to achieve an another erection up to 24
to 36 hours.
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How does Cialis work?
In technical terms Cialis exerts its action
by effecting two enzymes, Cyclic guanosine monophosphate (cGMP)
and phosphodiesterase type 5 (PDE5) that play important roles
in erectile function. Sexual stimulation triggers the local release
of nitric oxide (NO) from nerves and endothelial cells in the
penis. NO stimulates an enzyme that catalyzes formation of cGMP
from the nucleotide guanosine 5-triphospate (GTP) in the penile
blood vessels and corpus cavernosum walls.
The cGMP causes vasodilation of arteries, allowing
the influx of blood into the corpus cavernosum. Increased blood
flow into the penis causes the erectile tissue to expand. When
the erectile tissue has expanded sufficiently, the veins draining
the corpus cavernosum become compressed. This decreases the outflow
of blood from the penis, and the blood remains in the corpus cavernosum
to keep the penis erect.
The enzyme PDE5 eventually causes degradation
of the cGMP, and the erection ends.
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What is the normal Cialis dose?
In Cialis clinical testing most men were administered
one 10 mg Cialis or 20 mg Cialis tablet per day.
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Are there any side effects with Cialis?
Most of the reported side effects during clinical
testing were mild to moderate, and their incidence diminished
with continued treatment. The most commonly reported side effects
were myalgia (muscle pain), headache and upset stomach. There
were no clinically significant changes in heart rate, electrocardiograms,
blood pressure or laboratory tests attributable to treatment with
Cialis.The severities of these Cialis side effects were minimized
with lower doses of Cialis.
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How much time must surpass before Cialis
is effective?
Cialis is rapidly absorbed. Most patients in
clinical trial reported that Cialis produced positive effects
within thirty minutes.
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What happens if there is no sexual stimulation
following the ingestion of Cialis?
Cialis is naturally eliminated from your body
in a few hours.
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What are the precautions/warnings concerning
Cialis?
Men who are taking medicines that contain nitrates
(Nitroglycerin) of any kind must never use Cialis. Patients should
not take Cialis even if you only take nitroglycerin medication
occasionally. There is also a potential for cardiac risk during
sexual activity in patients with preexisting cardiovascular disease.
Therefore, Cialis should not be used in men where sexual activity
is inadvisable because of their underlying cardiovascular status.
Individuals should inform their physician concerning all medications
they are taking, including those medications acquired by a prescription
as well as over the counter medicines. The use of Cialis offers
no protection against sexually transmitted diseases, including
HIV. Patients should continue to use protective measures necessary
to guard against these diseases. In case of an overdose, call
your physician immediately.
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Can I use Cialis with other medications?
Yes, it is generally safe to use Cialis while
on other medications, however some medicines may potentate the
effects of Cialis. Individuals should always consult with their
healthcare provider prior to taking any medication. Note Cialis
does have one absolute contraindication; individuals who are taking
medication-containing nitrates (even intermittently) should not
take Cialis.
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Why is Cialis absolutely contraindicated
in individuals who are currently taking medications containing
nitrates?
Cialis may increase the hypotensive effects
of nitrates to life threatening levels. Therefore, individuals
who are currently using nitrates in any form even intermittently
should not take Cialis. Nitrates are available in many medications;
sprays, ointments, skin patches, pastes and tablets dissolved
in the mouth. Nitrates are also found in illicit drugs such as
amyl nitrate or nitrite "Poppers". If you are unsure
if you are currently taking nitrates please value your health
and consult with your local physician or pharmacist.
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Can I get Cialis over the counter?
No, Cialis should only be taken by prescription
from a licensed physician. Regulations do not permit Cialis to
be taken without prescription. Secondary to the advent of the
internet individuals may now order Cialis online simply by completing
an online medical questionnaire. Subsequently, a licensed physician
will review your medical history and patient profile. If approved
for a Cialis prescription, your order shipped discreetly to your
home or office in 1-2 business days. (order Cialis online now).
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Should I use Cialis if I have not had
sexual intercourse in a long time?
Sexual activity can cause a strain on
the cardiovascular system. If you have not had any physical activity
or if you have any pre-existing medical conditions you should
consult with your local physician prior to using the medication.
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